Lady who could “smell” Parkinson’s disease led researchers to find 10 unique molecules on Parkinson’s suffers.
This may lead to early diagnosis.
Scientists sniff out Parkinson’s disease smell – http://www.bbc.co.uk/news/uk-scotland-42252411
First man to run a mile in less than 4 minutes. This was his hobbie, as a student. He was even more accomplished as a foctor and neuro scientist.
Amazing ! 🙂 Inspiring !
Obituary: Roger Bannister – http://www.bbc.co.uk/news/uk-11764114
The world’s most nutritious foods – http://www.bbc.com/future/story/20180126-the-100-most-nutritious-foods
A Key Enzyme
A new study has been able to extend the lifespan of worms and flies by inhibiting RNA polymerase III (Pol III). Since the enzyme is common to all animal species, including humans, researchers hope the discovery could lead to groundbreaking new therapies.
Researchers have long known that Pol III plays a key role in cell growth and the production of proteins, but recent insights revealed that when its activity was reduced during adulthood, the survival of yeast cells (as well as the longevity of flies and worms) could be extended by an average of 10 percent.
“We’ve uncovered a fundamental role for Pol III in adult flies and worms: its activity negatively impacts stem cell function, gut health and the animal’s survival,” commented first author Danny Filer of the UCL Institute of Healthy Ageing, in a press release. “When we inhibit its activity, we can improve all these. As Pol III has the same structure and function across species, we think its role in mammals and humans warrants investigation as it may lead to important therapies.”
Yeast, flies, and worms were selected for the study as they are not closely related, but all bear the enzyme. Various techniques, including insertional mutagenesis and RNA mediated interference, were used to inhibit Pol III and observe the results.
When it was inhibited in the gut of flies and worms, they lived longer. This was also the case when it was inhibited in only the flies’ intestinal stem cells.
The results of Pol III inhibition have been compared to reactions to the immune-suppressing drug rapamycin, which is taken by cancer patients and organ transplant recipients. The drug has previously been shown to extend the lifespan of dogs. This latest study could help researchers better understanding exactly how rapamycin actually works.
“We now think that Pol III promotes growth and accelerates aging in response to a signal inhibited by rapamycin and that inhibiting Pol III is sufficient to result in flies living longer as if they were given rapamycin,” said co-author Dr. Nazif Alic. “If we can investigate this mechanism further and across a wider range of species, we can develop targeted antiaging therapies.”
The rapamycin compound was first discovered on Easter Island and has since been used to create drugs capable of extending the lives of several species. However, there hasn’t been a study of its effects on human subjects — at least not yet.
Gaining a further understanding of the mechanism behind rapamycin could certainly make the idea of a human trial more tenable. The team plans to continue their research into how inhibiting Pol III effects an adult organism, and why doing so results in a longer lifespan. An anti-aging pill is still a long way off, but this type of research could provide some key foundational knowledge.
Open Season on Arctic Drilling
The GOP’s final tax plan was signed into law on December 22, 2017 after being passed by both the U.S. House of Representatives and the Senate. The first overhaul in 30 years, the plan will provide fiscal relief to the biggest American corporations while delivering modest tax cuts to individual filers. But buried in the law is a stipulation seemingly irrelevant to economic policy — one that almost certainly spells disaster for one of the country’s most precious wildlife havens. It’s a go-ahead for Arctic drilling.
A provision snuck into the new legislation gives the okay to drill for oil and gas in Alaska’s Arctic National Wildlife Refuge (ANWR). One of the U.S.’ largest natural reserves, the refuge is home to a jigsaw puzzle of biodiversity, from migratory birds to threatened polar bears and caribou. The new law also takes management of the area away from the U.S. Fish and Wildlife Service.
The government believes that opening the reserve to oil and gas exploration could help plug the gap left by the tax cuts. But while the Senate Energy and Natural Resources Committee expects drilling generate an additional $1 billion in revenue from oil leases, an analysis by the Center for American Progress found that the operation is likely to yield no more than $37.5 million.
And according to estimates from the nonpartisan Joint Committee on Taxation, the law as a whole will leave the public purse short of $1.46 trillion over a decade.
“Even if that billion dollars were to materialize,” Niel Lawrence, Alaska director for the Natural Resources Defense Council told Futurism, “the annual income would not have paid a single day’s interest on the trillion and a half dollars [of debt] that this bill creates. The idea that this is a budgetary matter is a fiction pure and simple.”
The refuge’s nearly 19.3 million acres have been a key battleground of party warfare for several decades, with the Republicans arguing for the economic promise of resources that may be buried underground. But nobody knows how much oil and gas are there, because the territory is still protected from seismic exploration.
“Drilling in the Arctic Ocean is a bad idea as a business proposition, almost as much as it is in terms of environmental impacts,” said Lawrence. He explained that because the refuge has been kept free from human presence, “there is no infrastructure in place, there are no pipelines, there are no roads, it would take years even before a potential oil company could start drilling on its own.” The expense, he said, would be so high that any potential investment would be extremely risky.
The idea of offsetting the costs of new tax breaks by drilling the Arctic comes despite dire warnings from the scientific community. The 2017 Arctic Report Card found that the polar region is warming so fast that it’s hard to estimate the environmental consequences for the coming years. And even if the climate pledges made under the Paris Agreement were improved enough to keep global warming under 2° C (35.6° F), the Arctic would still experience a 5° C (41° F) temperature increase.
Although this part of the law is in tune with the pro-fossil fuels agenda of many GOP members and President Trump, activists are ready to fight the provision every step of the way.
Critics of the law’s provision also argue that oil should be kept in the ground no matter the financial implications. Lawrence asserted that “the demand for oil will have to go down.” He said we’ve already discovered at least four times more fossil fuel reserves than we can burn over the next 30 years if we want to avoid the worst consequences of climate change.
Rules of memory ‘beautifully’ rewritten – http://www.bbc.co.uk/news/health-39518580
New research may hold clues for treatment of Alseimer’s disease and other memory related issues.